ImmunologybioRxiv
Exploration of T-cell immune responses by expression of a dominant-negative SHP1 and SHP2
J. Taylor, A. Bulek, I. Gannon…·S. Thomas
This study investigates the role of SHP1 and SHP2 in T-cell immunosuppression by expressing truncated variants and shows that dSHP2 can alleviate PD1-mediated suppression in CAR T cells.
DOI 10.3389/fimmu.2023.1119350