J. Taylor

A Pooled CRISPR Screen Protocol for Comparative Pathway Analysis Across Multiple Stressors

This paper introduces a refined CRISPR screening protocol to compare cellular responses across multiple stressors, reducing false positives by 40% through fluorescence-based reporters and fixation steps.

Alternative splicing expands the antiviral IFITM repertoire in Chinese horseshoe bats

The paper identifies alternative splicing of IFITM genes in Chinese horseshoe bats, producing two isoforms with differential antiviral activities against influenza and coronaviruses.

Together, Neuropilin 1 and Neuropilin 2 direct α5 integrin trafficking through GTPase-activating-protein p120RasGAP in endothelial cells to promote fibronectin fibrillogenesis

This study identifies NRP1 and NRP2's role in regulating α5 integrin trafficking via p120RasGAP in endothelial cells, promoting fibronectin fibrillogenesis.

Exploration of T-cell immune responses by expression of a dominant-negative SHP1 and SHP2

This study investigates the role of SHP1 and SHP2 in T-cell immunosuppression by expressing truncated variants and shows that dSHP2 can alleviate PD1-mediated suppression in CAR T cells.

Hypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer

This study identifies hypoxia-induced NDR2 activation as a driver of brain metastases in NSCLC, showing NDR2 overexpression correlates with metastatic potential and can be measured via immunohistochemistry.

Barley MLA3 recognizes the host-specificity determinant PWL2 from rice blast (M. oryzae)

The paper shows that the barley NLR Mla3 recognizes the rice blast effector PWL2, conferring resistance in a dosage-dependent manner.

Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS/AML

The paper shows SF3B1 splicing modulators impair DNA damage response in cohesin-mutant MDS/AML, leading to increased sensitivity to PARP inhibitors and chemotherapy.

The Solanum americanum pangenome and effectoromics reveal new resistance genes against potato late blight

The paper identifies novel resistance genes in Solanum americanum against Phytophthora infestans by analyzing genome variation and effector recognition.

Cannabis sativa oxylipin biosynthesis: Genome-wide characterization of lipoxygenase, allene oxide synthase, allene oxide cyclase, hydroperoxide lyase, and 12-oxo-phytodienoic acid reductase gene families

This study identifies and characterizes oxylipin biosynthesis genes in Cannabis sativa, revealing their genomic organization and expression patterns across tissues and cultivars.

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths

This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.

Shedding Light on functional Near Infrared Spectroscopy and Open Science Practices

This review reflects on open science practices in fNIRS research and outlines goals for the next decade.

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

Modulation of the extracellular matrix by Streptococcus gallolyticus subsp. gallolyticus and importance in cell proliferation

This study shows Streptococcus gallolyticus subsp. gallolyticus upregulates collagen expression in CRC cells, which mediates its ability to promote cell proliferation and tumor growth.

Genetic basis and adaptive implications of temperature-dependent and temperature-independent effects of drought on chickpea phenology

This study identifies genomic regions and candidate genes associated with drought effects on chickpea phenology, revealing temperature-independent and temperature-dependent mechanisms and their adaptive implications.

Endothelial Rbpj is essential for the education of tumour-associated macrophages

This study shows that endothelial Rbpj promotes TAM education in EOC by regulating CXCL2, which drives CD44 expression and cholesterol depletion in TAMs, creating an immunosuppressive TME.

A lineage-specific Exo70 is required for receptor kinase-mediated immunity in barley

The paper identifies a lineage-specific Exo70FX12 gene required for Rps8-mediated immunity in barley against wheat stripe rust.

Implicit adaptation to mirror-reversal is in the correct coordinate system but the wrong direction

The paper investigates implicit learning in mirror-reversal tasks and finds that implicit adaptation occurs in the wrong direction but uses the correct coordinate system for different perturbations.

Sponges are highly resistant to radiation exposure and cancer

This study exposes sponges to high radiation doses and finds they resist cancer, with overexpressed DNA repair genes and no cancer induction.

Tissue-resident CD4+ T helper cells assist protective respiratory mucosal B and CD8+ T cell memory responses

This study identifies tissue-resident CD4+ T helper (TRH) cells that support local B and CD8+ T cell memory responses in the lung after influenza infection.

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis

The paper identifies sex-biased ZRSR2 mutations in BPDCN that impair pDC activation and apoptosis, linking X chromosome mutations to male-predominant leukemia.

Pangenome of white lupin provides insights into the diversity of the species

The paper constructs a white lupin pangenome to explore genetic diversity and identifies a deletion linked to late flowering, offering insights for breeding improved cultivars.

Identification of compounds producing non-visual photosensation via TrpA1 in zebrafish

The paper identifies compounds that induce non-visual photosensation via TRPA1 in zebrafish by increasing light-elicited motor activity.

Spatially discrete signalling niches regulate fibroblast heterogeneity in human lung cancer

The paper identifies fibroblast subpopulations in lung cancer using single-cell RNA sequencing and shows their spatial distribution and regulation by TGF-β1 and IL-1.

Cellular life from the three domains and viruses are transcriptionally active in a hypersaline desert community

The paper investigates transcriptional activity in a hypersaline desert microbiome, revealing eukaryotes as primary producers and identifying active halophilic viruses.

Greenhouse spatial effects detected in the barley (Hordeum vulgare L.) epigenome underlie stochasticity of DNA methylation

The paper shows that environmental micro-variations during growth affect DNA methylation in barley, linking previously stochastic epigenetic changes to greenhouse conditions.

Hidden dynamic signatures drive substrate selectivity in the disordered phosphoproteome

The paper develops a statistical thermodynamic framework to analyze conformational dynamics in the phosphoproteome and introduces a phosphorylation site predictor, PHOSforUS.

Halophilic microbial community compositional shift after a rare rainfall in the Atacama Desert

The paper studies microbial community shifts in the Atacama Desert after a rare rainfall, identifying two modes of response: a rapid Type 1 shift and a gradual Type 2 adjustment.

High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.

Global climate changes will lead to regionally divergent trajectories for ectomycorrhizal communities in North American Pinaceae forests

The paper predicts regionally divergent declines in ectomycorrhizal fungal richness and composition in North American Pinaceae forests under climate change, with mitigation reducing but not preventing losses.

Point of care influenza testing using Alere-i Influenza A & B assay: a practical assessment

The paper evaluates the Alere i Influenza A & B point of care test's performance compared to RT-PCR in hospitalized adults, finding high sensitivity and specificity but a notable test failure rate.