Exploration of T-cell immune responses by expression of a dominant-negative SHP1 and SHP2
J. Taylor, A. Bulek, I. Gannon, M. Robson, E. Kokalaki, T. Grothier, C. McKenzie, M. El-Kholy, M. Stavrou, C. Traynor-White, W. C. Lim, P. Panagiotou, S. Srivastava, V. Baldan, J. Sillibourne, , S. Thomas
This study investigates the role of SHP1 and SHP2 in T-cell immunosuppression by expressing truncated variants and shows that dSHP2 can alleviate PD1-mediated suppression in CAR T cells.
bioRxiv · Apr 26, 2023Immunology