M. Ferrari

Exploration of T-cell immune responses by expression of a dominant-negative SHP1 and SHP2

This study investigates the role of SHP1 and SHP2 in T-cell immunosuppression by expressing truncated variants and shows that dSHP2 can alleviate PD1-mediated suppression in CAR T cells.

Influenza A (N1-N9) and Influenza B (B/Vic and B/Yam) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine design

The paper develops NA pseudotype vectors and a pELLA assay to measure neuraminidase inhibition, showing improved sensitivity over existing methods for vaccine immunogenicity assessment.

Nutrient limitation magnifies fitness costs of antimalarial drug resistance mutations

This study shows that fitness costs of antimalarial drug resistance mutations are significantly higher in nutrient-limited media compared to standard RPMI, suggesting underestimation in typical lab conditions.

Establishment of pan-Influenza A (H1-H18) and pan-Influenza B (pre-split, Vic/Yam) Pseudotype Libraries for efficient vaccine antigen selection

The paper develops HA pseudotype libraries for Influenza A and B to improve vaccine antigen selection and neutralization assay capabilities.

Characterisation of a novel ACE2-based therapeutic with enhanced rather than reduced activity against SARS-CoV2 variants

The paper characterizes a novel ACE2-based therapeutic that effectively neutralizes SARS-CoV-2 variants and demonstrates antibody-like properties and manufacturability.

Preventive efficacy of a tenofovir alafenamide fumarate nanofluidic implant in SHIV-challenged nonhuman primates

This study evaluates a long-acting tenofovir alafenamide nanofluidic implant in nonhuman primates, showing partial protection against SHIV infection.