Insulin inhibits protein phosphatase 2A to impair β-adrenergic receptor function
A. Sahu, Y. Sun, S. Mukherjee, C. Witherow, K. Stenson, J. J. G. Tesmer, M. Mohan, S. N. Naga Prasad
This study shows insulin impairs β2AR function via GRK2 and PP2A inhibition, with PI3Kγ regulating PP2A to sustain β2AR phosphorylation.
bioRxiv · Sep 17, 2020 · PreprintBiochemistry