Y. Sun

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

The paper examines how sequential Omicron infections affect ancestral SARS-CoV-2 immune imprinting, finding that it persists on the RBD but not the NTD.

Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response

This study identifies how the coronavirus N protein disrupts nucleocytoplasmic trafficking and suppresses the innate immune response by promoting RACK1-PKC interaction and NUP62 phosphorylation.

Membranous translation platforms in the chloroplast of Chlamydomonas reinhardtii

The paper identifies two distinct membranous platforms in chloroplasts of Chlamydomonas reinhardtii involved in translation and thylakoid membrane biogenesis during chloroplast development.

The Impact of Preprints on the Citations of Journal Articles Related to COVID-19

This study compares citation counts of COVID-19 papers distributed as preprints versus those directly submitted to journals, finding preprints received significantly more citations in 70.11% of journals.

Synthesis of K+ channel radioligand 5-methyl-3-fluoro-4-aminopyridine and PET imaging in mice

This paper synthesizes [18F]5Me3F4AP, a K+ channel PET radioligand, and demonstrates its brain uptake and kinetics in mice, suggesting it as a potential improved tracer for demyelination imaging.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Reversible control of kinase signaling through chemical-induced dephosphorylation

This study uses an ABA-induced proximity system to reversibly control kinase signaling by recruiting phosphatases, revealing how phosphatases regulate oncogenic kinases like BCR::ABL1, BRAF(V600E), and MEK1.

TurboID-mediated surface protein biotinylation to inhibit the growth of Staphylococcus aureus

This study uses TurboID-mediated biotinylation of surface proteins to inhibit the growth and virulence of multiple S. aureus strains.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Automatic semantic segmentation of the osseous structures of the paranasal sinuses

The paper introduces an open-source model for automatically segmenting osseous structures of the paranasal sinuses, achieving high accuracy in ex vivo CT scans.

Phase-Separating Peptide Coacervates with Programmable Material Properties for Universal Intracellular Delivery of Macromolecules

This study manipulates phase-separating peptide sequences to control coacervate microdroplet properties and intracellular delivery kinetics of macromolecules.

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

Nitazoxanide ameliorates OVA-induced airway inflammation in asthmatic mice via p38-MAPK/ NFκB and AMPK/STAT3 pathways

This study shows nitazoxanide reduces airway inflammation in asthmatic mice by inhibiting NFκB/MAPK and AMPK/STAT3 pathways.

Nitrous Oxide Formation and Consumption in Thawing Permafrost: A Microcosm Study

This study investigates N2O formation and consumption in thawing permafrost using microcosms, finding that N2O formation exceeds consumption, likely driven by non-denitrifying bacteria.

Combining Scalable Organ Chip Platform with Deep Learning-Based Imaging Analysis for Cancer Therapeutic Screening

The paper combines an organ chip platform with deep learning for drug response analysis in cancer models, showing improved accuracy over traditional methods.

Cadmium Disrupts Blood-Testis Barrier (BTB) via An Oxidative Stress-Dependent Autophagy in Prepubertal Rats

This study shows cadmium exposure disrupts blood-testis barrier function in prepubertal rats via oxidative stress-induced autophagy and mTOR2 signaling impairment.

Peptide sequencing via reverse translation of peptides into DNA

This paper introduces a method to sequence peptides by converting them into DNA barcodes and demonstrates its ability to detect single amino acid substitutions and post-translational modifications.

The Impact of Preprints on COVID-19 Research Dissemination: A Quantitative Analysis of Journal Publications

The paper quantifies the role of preprints in COVID-19 research dissemination, showing their increased acceptance in high-impact journals.

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

Stearoyl coenzyme A desaturase 1 (SCD1) regulates foot-and-mouth disease virus replication by modulating host cell lipid metabolism and 2C-mediated replication complex formation

This study shows SCD1 regulates FMDV replication by modulating lipid metabolism and 2C-mediated replication complex formation, suggesting it as a potential drug target for positive-sense RNA viruses.

The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid

This study identifies a signaling relay system involving maternal vGluT2 and embryonic mGluR3 that controls offspring wing dimorphism in pea aphids through transgenerational phenotypic plasticity.

Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatment

This study identifies PRMT inhibitors as effective combinational therapies with PARP inhibitors to sensitize HR-proficient ovarian and breast cancer cells to treatment.

The dual resistance mechanism of CYP325G4 and CYP6AA9 in Culex pipiens pallens legs according to transcriptome and proteome analysis

This study identifies CYP325G4 and CYP6AA9 as key P450 enzymes involved in deltamethrin resistance in Culex pipiens legs through transcriptome and proteome analysis.

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.

CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis

The paper identifies CCR7+ dendritic cells as the primary source of IL-23 in psoriasis, linking them to type 17 inflammation and relapse.

Production, analysis, and safety assessment of a soil and plant-based natural material with microbiome- and immune-modulatory effects

This study standardizes the production of a soil and plant-based material, assesses its microbial content and safety, and demonstrates its potential to modulate the microbiome and immune system without adverse effects.

A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide

This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Circadian control of kidney regeneration via Lima1-mediated regulation of EMT

This study investigates the role of circadian clock genes in kidney regeneration using zebrafish, finding that per1 and nr1d1 promote regeneration by repressing lima1a, which regulates EMT.