Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction
J. D. Wang, B. W. Anderson, K. Liu, C. Wolak, K. Dubiel, K. A. Satyshur, J. Keck
The paper identifies a conserved (p)ppGpp binding motif in HPRT across species, showing that ligand binding varies with dimer-dimer interactions that evolved to regulate purine homeostasis.
bioRxiv · Apr 28, 2019Biochemistry