B. W. Anderson

This study shows (p)ppGpp acts as a co-repressor of PurR in Firmicutes, downregulating purine synthesis by enhancing PurR DNA binding, with implications across environments from the gut to pathogens.

The paper identifies pGpp as a third alarmone in Bacillus and shows NahA converts (p)ppGpp to pGpp, altering alarmone composition and stress response.

This study identifies how alarmones pppGpp, ppGpp, and pGpp inhibit XPRT activity by competing with PRPP, revealing structural and regulatory differences between XPRT and HPRT.

The paper identifies a conserved (p)ppGpp binding motif in HPRT across species, showing that ligand binding varies with dimer-dimer interactions that evolved to regulate purine homeostasis.