K. Liu

Uncovering the hidden RNA virus diversity in Lake Nam Co: evolutionary insights from an extreme high-altitude environment

This study identifies 742 RNA virus species in Lake Nam Co, revealing novel viral groups and evolutionary adaptations in an extreme high-altitude environment.

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

Comparison of therapeutic effects between pulsed field ablation and cryoballoon ablation in the treatment of atrial fibrillation: a systematic review and me-ta-analysis

This study compares pulsed field ablation (PFA) and cryoballoon ablation (CBA) for atrial fibrillation treatment, finding PFA reduces surgical time and complications but not arrhythmia recurrence.

Redefining FLASH RT: the impact of mean dose rate and dose per pulse in the gastrointestinal tract

This study evaluates how varying radiation beam parameters affect gastrointestinal toxicity and tumor response in mice, finding that high dose per pulse and ultra-high dose rate independently reduce toxicity while maintaining tumor control.

Jumbo phages possess independent synthesis and utilization systems of NAD+

This study identifies NAD-jumbo phages, which synthesize and utilize NAD+ for their life cycle, and finds they are widespread in various ecosystems.

Tumoroid-on-a-Plate (ToP): Physiologically Relevant Cancer Model Generation and Therapeutic Screening

This study introduces a 3D tumor model called ToP for generating predictive cancer models and screening therapeutics for glioblastoma and pancreatic adenocarcinoma.

Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

This study shows capsaicin directly binds KEAP1 and allosterically activates NRF2, reducing ethanol-induced gastric oxidative damage and suggesting its potential as a novel NRF2 agonist for oxidative stress-related diseases.

Harnessing Bilayer Biomaterial Delivery of FTY720 as an Immunotherapy to Accelerate Oral Wound Healing

Bilayer FTY720-nanofiber scaffolds promote complete oral wound closure in a mouse model by modulating pro-regenerative immune and stromal cells.

NS2B-D55E and NS2B-E65D Variations are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

Comparative analysis of methodologies for detecting extrachromosomal circular DNA

This study compares 7 analysis pipelines and 7 experimental methods for detecting extrachromosomal circular DNA, identifying the most effective approaches for short-read and long-read sequencing data.

RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1G93A ALS mice

This study introduces RD-12500, an siRNA conjugate that effectively reduces SOD1 levels and delays disease progression in late-stage SOD1G93A ALS mice.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

pathCLIP: Detection of Genes and Gene Relations from Biological Pathway Figures through Image-Text Contrastive Learning

The paper introduces pathCLIP, a system that identifies genes and gene relations from biological pathway figures using image-text contrastive learning, outperforming single-modality approaches.

VLIB: Unveiling insights through Visual and Linguistic Integration of Biorxiv data relevant to cancer via Multimodal Large Language Model

This paper introduces VLIB, a dataset of scientific figures and captions from cancer biology preprints, and evaluates MLLMs on vision-language tasks using it.

Integrating cellular graph embeddings with tumor morphological features to predict in-silico spatial transcriptomics from H&E images

The paper develops a deep learning method to predict spatial transcriptomics data from H&E images using graph neural networks and Vision Transformers, identifying 250 breast cancer-related genes.

Cryo-EM structure of the Spo11 core complex bound to DNA

The paper reports cryo-EM structures of Spo11 core complexes bound to DNA, revealing DNA-binding specificity and structural variation in homologs.

Quantitative dynamics of intracellular NMN by genetically encoded biosensor

This study develops a genetically encoded biosensor to measure intracellular NMN dynamics in live cells and identifies Slc25a45 as a potential mitochondrial NMN transporter.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

PD-L1 Restrains the PD-1hiNrp1loTGFb+ Treg to block IL6+ Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

This study shows PD-L1 suppresses inflammation-driven colorectal cancer by regulating Tregs, neutrophils, and gut microbiota through the PD-L1/L. murinus/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway.

Neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from ZF2001 RBD-dimer and its next-generation vaccines

This study evaluates the neutralization of SARS-CoV-2 EG.5/EG.5.1 by sera from vaccinated individuals and breakthrough infections, finding that next-generation vaccines offer better protection against these variants.

Distinct mechanisms by which antioxidant transcription factors Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of Cisplatin on hepatoma cells

This study investigates how antioxidant transcription factors Nrf1 and Nrf2 influence the anticancer effect of Cisplatin on hepatoma cells through distinct molecular mechanisms.

Simulated musculoskeletal optimization for sprinting and marathon running

This study develops a differentiable musculoskeletal simulator to optimize sprinting and marathon running performance, revealing new insights into muscle distribution and hip musculature importance.

SLC12A9 is a lysosome-detoxifying ammonium - chloride co-transporter

This study identifies SLC12A9 as a lysosomal ammonium exporter that maintains lysosomal homeostasis by transporting ammonium and chloride.

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

Single-cell transcriptomics reveals that tumor-infiltrating natural killer cells are activated by localized ablative immunotherapy and share anti-tumor signatures induced by immune checkpoint inhibitors

This study shows that localized ablative immunotherapy activates NK cells and shares anti-tumor gene signatures with immune checkpoint inhibitors, correlating with improved patient survival.

A beneficial adaptive role for CHOP in driving cell fate selection during ER stress

This study shows CHOP promotes cell death in some cells and proliferation in others during ER stress, providing a competitive growth advantage through stress-specific adaptation.