C.-m. Lehr

Simulated tempering-enhanced umbrella sampling improves convergence of free energy calculations of drug membrane permeation

This study introduces STeUS, a method combining simulated tempering and umbrella sampling to improve convergence of free energy calculations for drug membrane permeation, showing significant acceleration for bulky molecules.

Second-generation lung-on-a-chip array with a stretchable biological membrane

This paper introduces a second-generation lung-on-a-chip with a stretchable biological membrane that better mimics the lung parenchyma and air-blood barrier, preserving barrier properties for three weeks.