CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity
Jack C. Moore, Haruki Takeuchi, Caitlien Nguyen, Chin Cheng Huang, Digantkumar Gopaldas Chapla, Amrita Basu, Zhangjie Wang, Jian Liu, Kelley W. Moremen, Ryan J. Weiss
The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.
bioRxiv · Jun 30, 2026 · PreprintCell Biology