Zhangjie Wang

This study identifies an RBP-J-HS-dependent network that regulates macrophage fate between inflammation and osteoclastogenesis in response to TNF.

The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

This study shows that Sulf-2 promotes HNSCC cell invasion in co-cultures with CAFs, and a marine glycosaminoglycan inhibits this effect.

This study identifies heparan sulfate as a key regulator of TRAIL-induced apoptosis, showing that HS enhances TRAIL's apoptotic activity by promoting oligomerization and DR5 internalization.