Oncohistone inhibition reshapes tumor-microenvironment communication in Diffuse Midline Glioma (DMG)
Niloofar Khairkhah, Mostafa M.H. Ibrahim, Sienna L. Galban, Megan Faunce, Lily Rober, Carlen baker, Robert Doherty, Rodrigo Cartaxo, Carl Koschmann, Yue Zhao, Stefanie Galban
This study shows that H3K27M oncohistone reshapes the tumor microenvironment in DMG by altering neuronal interactions and immune signaling, suggesting it as a therapeutic target.
bioRxiv · Sep 16, 2026 · PreprintCancer Biology