Yue Zhao

This study shows that H3K27M oncohistone reshapes the tumor microenvironment in DMG by altering neuronal interactions and immune signaling, suggesting it as a therapeutic target.

The paper identifies 2'-O-methylation as a site-specific inhibitor of translation initiation by disrupting hydrogen bonds between mRNA start codons and 18S rRNA.

This paper develops a live-attenuated Toxoplasma vaccine by knocking out DGAT1, showing it provides long-term protection against both acute and chronic toxoplasmosis.

This study identifies IκBδ as a factor that enhances CD8 T cell accumulation and effector functions in solid tumors by overcoming constraints on T cell survival and cytotoxic capacity.

This study shows that aging disrupts circadian rhythms, leading to sex- and time-of-day-dependent changes in senescence and inflammatory pathways in mice.

The paper uses single cell RNA-sequencing and genome-wide association study data to identify cell types and processes involved in Barrett's esophagus and esophageal adenocarcinoma risk.

The paper identifies a basal-like subtype in esophageal adenocarcinoma associated with relapse after chemoradiation and poor survival.

This study finds higher inbreeding and purging of mutational load in wild Amur tigers compared to captive individuals, suggesting purifying selection reduces deleterious alleles in wild populations.