Author

Carmen Methner

Oregon Health & Science University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Sanjiv KauliD· 4 shared Alberto Parazzoli· 3 shared Jessica Franchi· 3 shared Agostino CianciulliiD· 2 shared allura thompsoniD· 2 shared Annalisa Pellacani· 2 shared chiara marcheselli· 2 shared D. Elizabeth LeiD· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

Sanjiv KaulORCID

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Author profile →

4 papers

Recent·Most cited

Impact of GPR39 Inhibition on Tissue Oxygen Tension in Acute Myocardial Infarction: Modeling Using an Indirect Response Pharmacokinetics/Pharmacodynamics Approach

Davide Ronchi, Chiara Roversi, Simone Zannoni, Alessandro De Carlo, Roberto Visentin, Annalisa Pellacani, Lisa Morbioli, Jessica Franchi, Carmen Methner, Marco Pergher, Alessia Tagliavini, Alberto Parazzoli, Sanjiv Kaul

This paper develops a population PK/PD model to simulate the effects of VC108, a GPR39 inhibitor, on myocardial oxygen tension during acute myocardial infarction and reperfusion.

bioRxiv · Sep 29, 2026 · PreprintPharmacology & Toxicology

Selective Pharmacological Blockade of GPR39 Markedly Reduces No Reflow and Infarct Volumes in a Rat Acute Myocardial Infarction When Administered Prior to Reperfusion

Carmen Methner, Mary Plascencia, allura thompson, Lijuan Liu, Masaki Kajimoto, D. Elizabeth Le, Agostino Cianciulli, Annalisa Pellacani, Jessica Franchi, chiara marcheselli, Alberto Parazzoli, Fabrizio Micheli, Sanjiv Kaul

Single intravenous bolus of the GPR39 antagonist VC108 shrank infarct and no-reflow volumes in rat myocardial infarction when given before reperfusion, but not 30 min after reperfusion.

bioRxiv · Aug 14, 2026 · PreprintPhysiology✦ In-depth digest

15-Hydroxyeicosatetraenoic Acid and GPR39 Together Orchestrate Coronary Autoregulation: A Comprehensive Metabolomic Analysis

D. Elizabeth Le, Masaki Kajimoto, Yan Zhao, Carmen Methner, Zhiping Cao, Jessica Minner, Agostino Cianciulli, Teresa Semeraro, Iuni Margaret Laura Trist, Jessica Franchi, chiara marcheselli, Alberto Parazzoli, Fabrizio Micheli, Sanjiv Kaul

This paper identifies GPR39 and 15-HETE as key regulators of coronary autoregulation through in vivo experiments and metabolomic analysis in dogs.

bioRxiv · Aug 9, 2026 · PreprintPhysiology

Deletion of GPR39 Prevents Pulmonary Arterial Hypertension by Attenuating Hypoxia-Induced Aberrant Signaling

Carmen Methner, Lijuan Liu, allura thompson, Mary Plascencia, Priyanka Chakravarty, Sanjiv Kaul

This study shows that deleting GPR39 prevents pulmonary arterial hypertension by reducing hypoxia-induced signaling and vascular remodeling.

bioRxiv · Jul 2, 2026 · PreprintPhysiology