A Druggable G Protein Checkpoint in Cholesterol Efflux
Gajanan Dattatray Katkar, Mahitha Shree Anandachar, Celia R. Espinoza, Megan L. Estanol, Caroline Biggs, Michelle Nacayama, Shu-Tsing Hsu, Ellie Tam, Raktim Mukharjee, Ella McLaren, Stephanie Aviles, Vanessa Castillo, Yashaswat S. Malhotra, Madhubanti Mullick, Armando Aaron, , Pradipta Ghosh
The paper identifies GIV as a macrophage checkpoint suppressing reverse cholesterol transport and shows its inhibition restores cholesterol efflux, reducing plaque burden and systemic lipid overload.
bioRxiv · Jun 24, 2026 · PreprintImmunology