ImmunologybioRxivPreprint
A Druggable G Protein Checkpoint in Cholesterol Efflux
Gajanan Dattatray Katkar, Mahitha Shree Anandachar, Celia R. Espinoza…·Pradipta Ghosh
The paper identifies GIV as a macrophage checkpoint suppressing reverse cholesterol transport and shows its inhibition restores cholesterol efflux, reducing plaque burden and systemic lipid overload.