Epitope-Focused Immunogens Confer Broad Protection against Coronaviruses
Mingxi Li, Qing Chen, Junghwa Seo, Yizhi Liu, Fred Zhangzhi Peng, Kexin Huang, Ziniu Dai, Changxu Chen, Zeli Zhang, Jincun Zhao, Zhaoqian Wang, Fajie Yuan, Xiancai Ma, David R. Martinez, Dapeng Li
This study designs epitope-focused immunogens targeting conserved coronavirus regions, showing broad neutralizing activity and protection in mice against diverse coronaviruses.
bioRxiv · Aug 4, 2026 · PreprintBioengineering