Author

Charley Wang

University of Southern California

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Adam J. de SmithiD· 2 shared Tanxin Liu· 2 shared Vijay G. SankaraniD· 2 shared Alexis CaulieriD· 1 shared Allison Zhang· 1 shared Andrew LeeiD· 1 shared Anna‐Lena NeehusiD· 1 shared Carmen Oleaga‐QuintasiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Adam J. de SmithORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition

Lara Wahlster, Anna‐Lena Neehus, Andrew Lee, Soumyaa Mazumder, Pardiss Mehrzad, Susan Black, Luana Messa, Tanxin Liu, Charley Wang, Chen Weng, Alexis Caulier, Jensen Pak, Travis J. Fleming, Mateusz Antoszewski, Allison Zhang, , Vijay G. Sankaran

The paper uses CRISPR and single-cell transcriptomics to study how inherited variants in B-cell development contribute to childhood leukemia.

bioRxiv · Aug 7, 2026 · PreprintCancer Biology

RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia

Tanxin Liu, Yanjie Li, Charley Wang, Cassandra J. Clark, Nathan Anderson, Erin L. Marcotte, Michael R. Lieber, Srividya Swaminathan, Joseph Leo Wiemels, Logan G. Spector, Vijay G. Sankaran, Carol Fries, Adam J. de Smith

The paper identifies RAG-mediated structural variants as a risk factor for relapse in pediatric B-ALL and T-ALL, independent of MRD status.

medRxiv · May 22, 2026 · PreprintGenetic & Genomic Medicine

Genome-scale analysis of interactions between genetic perturbations and natural variation

Joseph J. Hale, Takeshi Matsui, Ilan Goldstein, Martin N. Mullis, Kevin R. Roy, Christopher Ne Ville, Darach Miller, Charley Wang, Trevor W. Reynolds, Lars Michael Steinmetz, Sasha F. Levy, Ian M. Ehrenreich

The paper identifies gene-perturbation interactions across genetic backgrounds in yeast using CRISPRi and combinatorial DNA barcode sequencing, revealing 460 genes with variable effects and 234 interacting loci.

Nature Communications · May 18, 2024Peer-reviewedGenetics