Martin N. Mullis

This study identifies molecular changes in diet-restricted mice that correlate with lifespan and aging, highlighting key genes and pathways involved in longevity.

The paper uses genetic correlation analysis in DO mice to identify QTL and candidate genes linked to age-related pathologies.

This study identifies six longevity-associated loci in Diversity Outbred mice through a genetic meta-analysis of lifespan data from three studies, explaining over half of the heritable variation in lifespan.

This paper introduces an automated pipeline to quantify elastic fiber architecture in mouse aorta histology, enabling objective, high-throughput analysis of vascular structure.

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

The paper identifies gene-perturbation interactions across genetic backgrounds in yeast using CRISPRi and combinatorial DNA barcode sequencing, revealing 460 genes with variable effects and 234 interacting loci.

The paper identifies genetic loci influencing fungal persistence in different mammalian organs using a yeast model, showing complex interactions between general and organ-specific alleles.

The paper identifies multiple genetic loci influencing the expressivity of a spontaneous mutation in budding yeast.

The paper shows that in diploids, epistasis frequently modifies both additivity and dominance.