Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge
Giuditta De Lorenzo, Rapeepat Tandavanitj, Jennifer Doig, Chayanee Setthapramote, Monica Poggianella, Ricardo Sanchez Velazquez, Hannah E. Scales, Julia M. Edgar, Alain Kohl, James M Brewer, Oscar R. Burrone, Arvind H. Patel
This paper develops ZIKV vaccines using virus-like particles with covalently dimerized envelope protein, showing enhanced neutralization and protection against lethal ZIKV challenge in mice.
Journal of Virology · Dec 9, 2020Peer-reviewedMicrobiology