Human Pumilio proteins use fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex to repress mRNAs
Elise B. Dunshee, Brenna A Saladin, David J. Turner, Chen Qiu, Robert C. Dutcher, Jason Grant Williams, Joshua H. Corbo, Olivia R Wolcott, Amanda J Korte, Rebecca J. Haugen, Traci M. Tanaka Hall, Eugene Valkov, Aaron C. Goldstrohm
The paper identifies how human PUM proteins repress mRNAs by using fuzzy multivalent hydrophobic interactions to recruit the CCR4-NOT deadenylase complex through their intrinsically disordered RD3 domain.
Journal of Biological Chemistry · Feb 13, 2026Peer-reviewedMolecular Biology