Markus Hafner

RBProximity-CLIP maps RBP-RNA interactions at subcellular resolution, revealing compartment-specific targets for AGO2, YBX1, and ELAVL1.

This study shows that IGF2BP family proteins suppress RNA-sensing pathways by binding TNFAIP3 mRNA, reducing innate immune signaling in AML cells.

This study identifies DDX3X's role in regulating host and viral mRNA translation during Sendai Virus infection, revealing its direct interaction with IFNB1 5'UTR and its impact on IFN-β production.

The paper introduces RLP, a method to map subcellular RNA localization in single cells, revealing widespread heterogeneity undetectable by bulk methods.

PCLIPtools improves PAR-CLIP data analysis by identifying high-confidence RNA-protein interaction sites with greater precision and speed than existing tools.

This study identifies dysregulated U12-type splicing in lupus neutrophils, linking it to impaired Nox activity and immune dysfunction.

Human brain organoids show that a TDP-43 mutation causes RNA mis-splicing and neuronal stress in ALS.

This paper develops ProAPOBECs, engineered cytidine deaminases fused with PUF proteins, for effective RNA base editing in the brain, correcting mutations and reducing autistic-like behaviors in mice.

The paper identifies an RNA sequence motif recognized by the DND1-NANOS3 complex in germ cells and shows its role in regulating mRNA expression.

This study shows the MLLT3 YEATS domain binds both histone marks and the 7SK RNA, influencing hematopoietic lineage commitment and gene expression.

The paper identifies RNA-binding proteins involved in suppressing latent splice site activation, with ALYREF interacting with U5 snRNA to regulate splicing accuracy.

The paper identifies master regulatory miRNAs in glioblastoma and develops a therapeutic delivery method to inhibit tumor growth.

The paper develops a deep learning model to predict translation initiation and termination sites from RNA sequences, revealing new insights into translation control and identifying novel open reading frames.

This study investigates how antibiotics inhibit mitochondrial translation, finding that most act similarly to their bacterial targets and identifying errors in annotated mitochondrial translation initiation sites.

This study identifies MATRIN3 deficiency as a trigger for autoinflammation through cGAS-STING activation via mis-splicing of TDRD3 and R-loop formation.

This study analyzes Transcribed Ultra Conserved Regions (TUCRs) in gliomas, identifying uc.110 as a tumor enhancer that promotes malignancy via the WNT pathway.

This study identifies Matrin3's role in regulating CDC14B alternative splicing, which affects cell proliferation and mitotic spindle dynamics in colorectal cancer cells.

This study identifies that Keratin 19 sequesters HNRNPK in the cytoplasm, stabilizing mRNAs involved in cancer progression.

This study identifies RBM4 as a post-transcriptional regulator of endogenous retrovirus (ERV) expression using computational analysis and experimental validation.

The paper identifies DHX36 binding to G-rich mRNA regions and shows it reduces mRNA stability without increasing translation.