Author

Chen Xie

Peking University

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Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant effect prediction· 2 Assay:ChIP-seq· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Wenyang Dong· 2 shared Di Wang· 1 shared Dubai LiiD· 1 shared Hongen KangiD· 1 shared Jian YaniD· 1 shared Jiaxiang ZhangiD· 1 shared Jiecong LiniD· 1 shared Jun ReniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Wenyang Dong

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2 papers

Recent·Most cited

Prediction of Transcription Factor DNA Binding Affinity with High-Throughput Kd Measurements and Deep Learning

Zi Wang, Di Wang, Ke Shen, Junchen Luo, Xinyao Wang, Nan Wu, Yunzhi Lang, X Wang, Jun Ren, Wenyang Dong, Lu Pan, Yitong Lyu, Dubai Li, Chen Xie, Zhen Zhang, , Xiaoliang Sunney Xie

The paper introduces Seq2Kd, a deep learning model predicting TF-DNA binding affinity using high-throughput Kd measurements, and provides a web portal for functional genomics and disease research.

bioRxiv · May 20, 2026 · PreprintBiophysics

Genome-wide maps of transcription factor footprints identify noncoding variants rewiring gene regulatory networks

Jiecong Lin, Wenyang Dong, Jiaxiang Zhang, Chen Xie, Xiaoxi Jing, Junpeng Zhao, Kaiyan Ma, Hongen Kang, Yilin Jiang, Xiao Xie, Yajie Zhao

The paper identifies noncoding variants that alter gene regulatory networks using a combination of single-molecule deaminase footprinting and variant effect prediction, applied to UK Biobank genomes.

bioRxiv · Mar 25, 2026 · PreprintBioinformatics