Chen Xie

This paper quantifies binding cooperativity between adjacent transcription factors on DNA and identifies its functional roles in gene regulation.

The paper identifies sporadic over-activation of co-regulated genes with extreme outlier RNA expression in multiple species and tissues, showing these patterns are not inherited but may reflect gene regulatory network dynamics.

The paper examines sex-biased gene expression patterns in somatic tissues of mice and humans, finding rapid evolutionary turnover and overlapping variances that challenge a binary sex classification.

This paper uses patient-derived iPSC to generate cerebral organoids modeling ALS-PDC, showing BMAA exposure causes microglial M1 polarization and metabolic dysregulation.

The study shows that retroposition rates in natural mouse populations are much higher than previously thought, with most events being deleterious and affecting gene expression.

The paper studies three newly emerged genes in mice, showing they quickly integrate into functional networks without extensive adaptive changes.