NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress
Yi Xu, Michael H Nipper, Angel A. Dominguez, Chenhui He, Francis E. Sharkey, Sajid Khan, Han Xu, Daohong Zhou, Lei Zheng, Yu Luan, Jun Liu, Pei Wang
This study identifies NF2 as a critical tumor suppressor in PDAC, showing its role in promoting invasive behavior, enhancing cell fitness under stress, and contributing to drug resistance.
Journal of Clinical Investigation · Jan 1, 2026Peer-reviewedCancer Biology