Jun Liu

Ultrafast and Accurate Selection of High-Quality Protein Complex Models from Large-Scale Prediction

This paper introduces DeepUMQA-Selection, a framework for efficiently selecting high-quality protein complex models from large candidate pools, showing improved performance and speed.

Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity

This study identifies an early neutrophil interferon program that predicts resistance to anti-PD1 therapy and limits durable anti-tumor immunity.

The Sustained Alteration Of Brain Waves In Cynomolgus Macaques Following Aerosol Infection With Venezuelan Equine Encephalitis Virus Subtype IAB

This study tracks physiological and EEG changes in cynomolgus macaques after aerosol VEEV-IAB infection, showing rapid autonomic nervous system disruption and persistent EEG alterations without detectable viral persistence.

MANF Clears Mutant Uromodulin in Human Kidney Organoids of Autosomal Dominant Tubulointerstitial Kidney Disease

This study shows MANF reduces mutant uromodulin in kidney organoids by enhancing autophagy through IP3R1 repression, suggesting potential for treating ADTKD and similar protein misfolding diseases.

Pto evolved from malectin-like RLKs phosphorylates AvrPtoB to promote Prf-mediated immunity in Solanum pimpinellifolium

This study shows Pto phosphorylates AvrPtoB to enhance immunity in tomato and identifies evolutionary changes that stabilize Pto.

NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

This study identifies NF2 as a critical tumor suppressor in PDAC, showing its role in promoting invasive behavior, enhancing cell fitness under stress, and contributing to drug resistance.

A tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesis

This study identifies a single residue in ZIKV NS5 that modulates immune evasion, viral replication, and pathogenesis by affecting STAT2 degradation and IFN signaling.

The anaerobic WOR-3 Bacteria: Hydrogenotrophic metabolism and unique carbon fixation via Archaeal form III RuBisCO

This study analyzes 180 metagenome-assembled genomes of the WOR-3 phylum to reveal four subgroups with distinct metabolic capabilities, including carbon fixation via archaeal form III RuBisCO and versatile sulfur and nitrogen metabolism.

Gene Therapy Mediates Therapeutic Improvement in Cardiac Hypertrophy and Survival in a Murine Model of MYBPC3-Associated Cardiomyopathy

This study demonstrates that AAV gene therapy with TN-201 restores MYBPC3 protein levels, reverses cardiac hypertrophy, and improves survival in a murine model of MYBPC3-associated HCM.

Rapid riparian ecosystem recovery in low-latitudinal North China following the end-Permian mass extinction

This study shows rapid recovery of riparian ecosystems in low-latitude North China within 2 million years after the end-Permian mass extinction, marked by increased ichnological complexity and burrowing behavior.

Emerging many-to-one weighted mapping in hippocampus-amygdala network underlies memory formation

The paper identifies a 'many-to-one weighted mapping' mechanism in the hippocampus-amygdala network that supports memory formation through distinct coding strategies in dCA1 and BLA neurons.

Chemical genetics reveals cross-activation of plant developmental signaling by the immune peptide-receptor pathway

The paper identifies a small molecule that disrupts stomatal development by inhibiting a receptor-kinase pathway, showing cross-activation with immune signaling through MAP kinase interactions.

Solvent quality and chromosome folding in Escherichia coli

The paper investigates solvent quality for DNA in Escherichia coli and finds the cytoplasm is a poor solvent, leading to chromosome compaction and domain formation.

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

This study shows that human ACE2 transgenic mice infected with SARS-CoV-2 develop severe respiratory disease, with males more susceptible than females.

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.

Using a bar-coded AAV capsid library to select for novel clinically relevant gene therapy vectors

The paper develops a barcoded AAV capsid library to identify novel gene therapy vectors with improved transduction efficiency in human islets and hepatocytes.

Loss of a doublecortin (DCX) domain containing protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host cell invasion.

This study shows that TgDCX is essential for the structural integrity of the conoid in Toxoplasma gondii and its loss impairs host cell invasion.