SCN- induces prestin contraction through reduced intermonomer angles and a modified transporter like movement of each monomer.
Richard Mariadasse, Molly Powers, Jun-Ping Bai, Chenou Zhang, Sneha Subramaniya, Jie Yang, Fred J Sigworth, Venkat Kalyana Sundaram, Carmen Butan, Oliver Beckstein, Joseph Santos-Sacchi, Dhasakumar S Navaratnam
The paper investigates how SCN- induces prestin contraction through structural changes in its dimers and monomers, associated with altered intermonomer angles and beta sheet loss.
bioRxiv · Nov 3, 2026 · PreprintPhysiology