Rotamer Density Estimator is an Unsupervised Learner of the Effect of Mutations on Protein-Protein Interaction
Shitong Luo, Yufeng Su, Zuofan Wu, Chenpeng Su, Jian Peng, Jianzhu Ma
The paper introduces RDE, an unsupervised method that predicts mutation effects on protein-protein binding by estimating conformational flexibility from protein structures, outperforming existing methods.
bioRxiv · Feb 28, 2023 · PreprintBioinformatics