Rui Wang

Site-Specific Inhibition of Translation Initiation via 2'-O-methylation

The paper identifies 2'-O-methylation as a site-specific inhibitor of translation initiation by disrupting hydrogen bonds between mRNA start codons and 18S rRNA.

Mechano-Piezoelectric F-Peptide Hydrogels Enable In Situ Stem Cell and Immune Niche Modulation for Cartilage Regeneration

This paper develops a mechano-piezoelectric peptide hydrogel that modulates stem cell and immune niches to reverse osteoarthritis by combining piezoelectric cues with 4-OI loading.

Komagataella phaffii encodes two functional Pho4 transcription factors

The paper identifies two functional Pho4 transcription factors in Komagataella phaffii and shows they have overlapping but distinct roles in stress response.

Pseudomonas aeruginosa CRISPR-Cas primes a minimal proline-codon toxin to abort anti-CRISPR phages

The paper shows Pseudomonas aeruginosa uses a CRISPR-Cas system to silence a proline-codon toxin that stops phage growth, revealing a defense mechanism against anti-CRISPR phages.

Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure

This study identifies a compound that inhibits RhoA activation by stabilizing its GDP state, reducing myocardial remodeling and fibrosis in heart failure models.

Drift and isolation drive genomic erosion and island speciation in a lineage of macaques

The paper shows that island isolation and genetic drift rapidly drive speciation in macaques, leading to genomic divergence, loss of diversity, and adaptive mutations.

Sustained hippocampal theta-oscillations reflect experience-dependent learning in bidirectional temporal-order memory retrieval

The paper investigates how hippocampal theta oscillations relate to bidirectional temporal-order memory retrieval, finding increased theta activity during backward retrieval after learning.

Phage CRISPR-like regulatory RNAs silence multilayered bacterial immune systems

The paper identifies viral crlRNAs that suppress bacterial immunity by reprogramming Cas proteins and demonstrates their potential for mammalian genome editing.

High-resolution de novo structure prediction from primary sequence

From a single sequence, OmegaFold reaches mean LDDT 0.82 on 146 CAMEO targets, between MSA-based RoseTTAFold (0.75) and AlphaFold2 (0.86), and runs about ten times faster.

Somatodendritic HCN channels in hippocampal OLM cells revealed by a convergence of computational models and experiments

The paper integrates computational models and experiments to show that hippocampal OLM cells have dendritic HCN2 channels, supporting theta spiking resonance.

Ten Simple Rules for Taking Advantage of git and GitHub

The paper provides guidelines on using git and GitHub for project tracking, collaboration, and code dissemination.