Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma
Yunzhan Li, Zekun Li, Qin Li, Dongxiao Sun, Bo Ni, Mingjun Tan, Ashley Elizabeth Shay, M. Wang, Chenyang Meng, Guangcong Shen, Boyang Fu, Yu Shan, Shiqi Zhang, Rifah Rownak Tanshee, Tianxing Zhou, , Shengyu Yang
This study shows that adaptation to cystine limitation stress in PDAC promotes tumor growth via lipid metabolism reprogramming, and lomitapide can inhibit this process and enhance chemotherapy.
Nature Communications · Dec 31, 2025Peer-reviewedCancer Biology