Yunzhan Li

This study shows that adaptation to cystine limitation stress in PDAC promotes tumor growth via lipid metabolism reprogramming, and lomitapide can inhibit this process and enhance chemotherapy.

This study identifies the BNIP3-mTOR signaling axis as a mediator of resistance to MET inhibition in glioblastoma and shows that combined MET and mTOR inhibition synergistically enhances anti-tumor effects.

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.