M. Wang

Evolutionary genomics of local adaptation, climate vulnerability, and linarin metabolism in Opisthopappus longilobus

This study presents the first chromosome-scale genome of Opisthopappus longilobus, identifies adaptive genes linked to climate stress, and links genetic divergence to metabolic differences between species.

Retinal nerve fibre layer thickness reflects characteristics of brain grey and white matter

The paper investigates associations between retinal nerve fibre layer thickness and brain grey/white matter structure, finding some links but not supporting cardiovascular risk factor associations.

Adaptation to cystine limitation stress confers a targetable lipid metabolism vulnerability in pancreatic ductal adenocarcinoma

This study shows that adaptation to cystine limitation stress in PDAC promotes tumor growth via lipid metabolism reprogramming, and lomitapide can inhibit this process and enhance chemotherapy.

The evolution of autonomy from two cooperative specialists in fluctuating environments

This study shows that autonomous genotypes can evolve from cooperative microbial specialists in fluctuating environments through horizontal gene transfer.

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

Divergent roles of SOX2 in human and mouse germ cell specification related to X-linked gene dosage effects

This study identifies how X-linked gene dosage affects human primordial germ cell-like cell (hPGCLC) specification, revealing species-specific roles of SOX2 and SOX17 influenced by escape genes.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

Multiple allostery in the regulation of PDGFR beta kinase activities

The paper identifies multiple allosteric mechanisms regulating PDGFRβ kinase activity and shows their conservation in other type III RTKs, with implications for disease.

Cold seeps are hotspots of deep-sea nitrogen-loss driven by microorganisms across 21 phyla

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

In vivo and in vitro analysis of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa

This paper clarifies the role of Prc protease in mucoid conversion of Pseudomonas aeruginosa by showing it directly degrades MucA22, a truncated form of MucA, and not wild-type MucA.

Aging represses lung tumorigenesis and alters tumor suppression

This study shows aging suppresses lung tumor initiation and growth in mice, with age-dependent effects on tumor suppressor genes like PTEN and persistent age-related transcriptomic changes in tumors.

In-brain construction of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry

The paper develops a method to modify receptor proteins in the living mouse brain with fluorescent probes using ligand-directed and click chemistry, enabling high-resolution mapping of matrix metalloproteinase-9 activity near AMPARs.

Mining the biosynthetic landscape of lactic acid bacteria unearths a new family of RiPPs assembled by a novel type of ThiF-like adenylyltransferases

The paper identifies a new family of RiPPs in lactic acid bacteria biosynthetic gene clusters, revealing a novel adenylyltransferase mechanism for macrocyclic imide formation.

Wheat Enhanced Disease Resistance EMS-Mutants Include Lesion-mimics With Adult Plant Resistance to Stripe Rust

The paper identifies 16 wheat mutants with enhanced resistance to stripe rust and other fungal pathogens through forward genetic screening and maps their mutations to a long-read genome.

Human CD29+/CD56+ myogenic progenitors display tenogenic differentiation potential and facilitate tendon regeneration

This study identifies human CD29+/CD56+ myogenic progenitors with tendon differentiation potential that improve tendon repair when transplanted.

Diversity and ecological potentials of viral assemblages from the seamount sediments of the Northwest Pacific Ocean

The paper analyzes viral diversity in seamount sediments, identifying 78,069 vOTUs and 16 vAMGs, suggesting ecological roles in biogeochemical cycles.

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

This study shows that microbiota from young mice reduces age-related gout susceptibility by increasing butyric acid and modulating uric acid metabolism in aged mice.

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

Insight into the Impact of Air Flow Rate on Algal-Bacterial Granules: Reactor Performance, Hydrodynamics by Computational Fluid Dynamics (CFD) and Microbial Community Analysis

This study examines how air flow rate affects nitrogen removal, granule formation, and microbial communities in algal-bacterial systems using CFD and microbial analysis.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

Chloride Homeostasis Regulates cGAS-STING Signaling

This study shows chloride homeostasis regulates cGAS-STING signaling by affecting 23-cGAMP production, STING polymerization, and cytokine production in immune cells.

A tale of two tumors: differential, but detrimental, effects of glioblastoma extracellular vesicles (EVs) on normal human brain cells

This study shows that glioblastoma extracellular vesicles induce different transcriptomic, secretomic, and proteomic effects on normal brain cells, yet all lead to increased tumorigenicity.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Molecular basis for condensin enrichment at pericentromeres

This study identifies a molecular mechanism by which condensin is recruited to pericentromeres through a conserved interaction between Ycg1 and Sgo1, ensuring proper chromosome segregation.

Neuroprotective Effects of Bioactive Molecules Derived from Tobacco as Potential Therapeutic Candidates for Alzheimer Disease

The paper identifies three tobacco-derived compounds with neuroprotective effects against Alzheimer's disease using a genetic engineering approach with neural progenitor cells.

Polyglutamylation of microtubules drives neuronal remodeling

The paper shows that polyglutamylation of microtubules regulates neuronal remodeling by marking them for severing, affecting synapse and axon pruning in both peripheral and central circuits.

Deletion of Nrf1 exacerbates oxidative stress-induced cellular senescence by disrupting the cell homeostasis

This study shows that deleting Nrf1 increases oxidative stress-induced cellular senescence by disrupting homeostasis, as evidenced by increased senescence markers and impaired autophagy.

The segmented flavivirus Alongshan virus reduces mitochondrial mass via degrading STAT2 to suppress innate immune response