Histology-aware Inference of Cell-cell Communication in Spatial Transcriptomics
Xiaofei Wang, Chenyang Tao, Yu Jiang, Yixuan Jiang, Hanyu Liu, Zheng Jiang, Pinan Zhu, Ningfeng Que, Jianzhong Xi, Stephen Price, Binzhi Qian, Jianguo Xu, Chao Li
This paper introduces HARMONIC, a framework that improves cell-cell communication inference in spatial transcriptomics by incorporating histology data, showing it better captures anatomical context.
bioRxiv · Oct 12, 2026 · PreprintBioinformatics