Chao Li

Deprivation of dietary fiber promotes low-grade neuroinflammation and anxiety-like behavior in mice

This study shows that depriving mice of fermentable dietary fiber leads to low-grade neuroinflammation and anxiety-like behavior, which are reversed by fiber supplementation.

Single-cell transcriptome-wide association analysis reveals epithelial cell-specific genetic susceptibility to colorectal cancer

The paper performs single-cell transcriptome-wide association analysis to identify cell-type-specific genetic susceptibility genes for colorectal cancer, finding 546 gene-cell-type associations and 347 candidate susceptibility genes.

Multimodal spatial-omics reveal the heterogeneity and intercellular network characteristics of papillary craniopharyngiomas.

This study uses multimodal spatial-omics to analyze papillary craniopharyngiomas, identifying tumor cell states and microenvironment interactions.

Field-Based Characterization of Temporal Interference Stimulation: Beyond the Target-Centric Perspective

This paper introduces a computational framework to characterize temporal interference stimulation fields using topological analysis and mesh-aware metrics, improving accuracy and interpretability of field assessment.

Tc17-driven antibody-independent mucosal immunity is critical for protection against extracellular bacterial pneumonia

This paper shows that mucosal mRNA vaccines protect against Kp pneumonia via Tc17 cells, not antibodies, and introduces an exosome platform enhancing vaccine efficacy.

Cell line resources for the study of neurofibromin: functions, phenotypes, and drug discovery/development

The paper presents and characterizes human cell lines with NF1 gene variants for studying neurofibromin function, phenotypes, and drug development.

Deconvolution-based cell-type specific DNA methylation-wide and transcriptome-wide association studies identify risk CpG sites and genes associated with colorectal cancer risk

The paper uses deconvolution to identify cell-type-specific DNA methylation and gene expression associations with colorectal cancer risk, finding 178 CpG sites and 68 genes across 26 new loci.

Gut Microbiota Dysbiosis Drives Myocardial Hypertrophy Through GBP2b/GBP1-Mediated Immune Reprogramming and Exosomal Signaling in Chronic Colitis

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

The paper maps cis-regulatory elements in the macaque cortex using snATAC-seq and links them to disease-related genes and risk SNPs.

Low level of viral intra-host diversity is associated with severe SFTS disease

The paper analyzes SFTSV intra-host diversity in patients with varying disease severity, finding lower diversity in severe cases despite higher viral loads and identifying iSNVs linked to replication and immunity.

GEI-17-Mediated SUMOylation of GDI-1 Regulates Apoptotic Cell Clearance

This study identifies GEI-17-mediated SUMOylation of GDI-1 as a mechanism regulating phagosomal degradation and apoptotic cell clearance in C. elegans and mammals.

Genetic and molecular mechanism for distinct clinical phenotypes conveyed by allelic truncating mutations implicated in FBN1

The paper investigates how different FBN1 truncating mutations cause distinct clinical phenotypes in Marfan syndrome and Marfanoid-progeroid-lipodystrophy syndrome through molecular and genetic analysis.

Overlooked polyploidies in lycophytes generalize their roles during the evolution of vascular plants

The paper reanalyzes the genome of Selaginella moellendroffii and finds multiple polyploidies, suggesting they played a key role in the evolution of vascular plants.