A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging
Lin Guo, Rui Zheng, Qianqian Zhan, Xin Yu, Qi Zhang, Jiaxi Yao, Xiaoqing Tan, Xin Li, Ou Zhang, Peiyun Liu, Chenghan Wang, Ye Yao, Rui Ma, Xiao Wu, Chenyuan Wang, , Wenqiang Cao
This study identifies an adenosine-Gzmk axis that drives T cell aging and systemic inflammaging, showing that targeting it can reverse aging phenotypes and extend lifespan in mice.
bioRxiv · Mar 20, 2026 · PreprintImmunology