Author

Lin Guo

China Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Andrei-Florian StoicaiD· 1 shared Andrew P. HutchinsiD· 1 shared Changyin YuiD· 1 shared Chenghan Wang· 1 shared Chenyuan Wang· 1 shared Congcong Xia· 1 shared Cuicui Xia· 1 shared Duanqing PeiiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperCell Biology

Andrei-Florian StoicaORCID

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Author profile →

4 papers

Recent·Most cited

A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging

Lin Guo, Rui Zheng, Qianqian Zhan, Xin Yu, Qi Zhang, Jiaxi Yao, Xiaoqing Tan, Xin Li, Ou Zhang, Peiyun Liu, Chenghan Wang, Ye Yao, Rui Ma, Xiao Wu, Chenyuan Wang, , Wenqiang Cao

This study identifies an adenosine-Gzmk axis that drives T cell aging and systemic inflammaging, showing that targeting it can reverse aging phenotypes and extend lifespan in mice.

bioRxiv · Mar 20, 2026 · PreprintImmunology

An Integrated Single-Cell Atlas Reveals Hepatic Stellate Cell Heterogeneity and Spatiotemporal Dynamics after Liver Injury

Jiongliang Wang, Jiawang Tao, Cuicui Xia, Miaoxiu Tang, Andrei-Florian Stoica, Shengxian Yuan, Yinxiong Li, Lin Guo, Xiangqian Kong, Jie Wang

This study constructs a cross-etiological HSC atlas to reveal HSC heterogeneity and spatiotemporal dynamics in liver injury, identifying a novel apoptosis-prone HSC subtype and a 531-gene fibrosis signature.

bioRxiv · Nov 25, 2025 · PreprintCell Biology

Astrocyte-specific secretome profiling reveals its correlation with neurological disorders

Jie Liu, Jing Gao, Lin Guo, Guoming Ma, Mingfeng Guan, Congcong Xia, Jia He, Yufang Yang, Yi Wu, Jun Xu, Liuling Xiong, Changyin Yu, Gang Pei, Jian Zhao, Jianchen He, , Wenyuan Wang

The paper develops a secretome profiling method for astrocytes and identifies proteins involved in disease-related toxicity and neuroprotection.

bioRxiv · Nov 21, 2024 · PreprintNeuroscience

Resolution of Reprogramming Transition States by Single Cell RNA-Sequencing

Lin Guo, Xiaoshan Wang, Mingwei Gao, Lihui Lin, Junqi Kuang, Yuanbang Mai, Fang Wu, He Liu, Jiaqi Yang, Shilong Chu, Hong Song, Yujian Liu, Jiadong Liu, Jinyong Wang, Guangjin Pan, , Duanqing Pei

Single cell RNA sequencing identifies two reprogramming branches in mouse fibroblasts, with Dppa5a marking pluripotent cells and IFN-gamma inhibiting the transition.

bioRxiv · Aug 30, 2017 · PreprintCell Biology