An LRH-1 agonist reverses hepatic metabolic dysfunction in obesity
Suzanne G Mays, André R Cuevas, Racheal M Spurlin, Rohini Polavarapu, Chih-yu Chen, Zhenxin Hou, Michael L Cato, Rita Swinger, Elizabeth J Millings, Autumn R Flynn, Debipreeta Bhowmik, Henry Zecca, Wen-Yu Hsiao, Sarah M Abraham, Alyssa M Johnson, , John W Calvert
This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.
bioRxiv · Nov 3, 2026 · PreprintPhysiology