Ivo Díaz Ludovico

The paper identifies carbamylation as a regulatory modification in β-cell metabolism and insulin processing in T1D by analyzing proteomic changes in NOD and MIN6 cells.

This study evaluates plasma extracellular vesicle proteomics for identifying predictive biomarkers of type 1 diabetes development, finding 448 differentially abundant proteins and a 0.81 AUC in predicting islet autoimmunity.

This study uses mass spectrometry to identify caspase targets in primary intestinal epithelial cells following NAIP-NLRC4 inflammasome activation, revealing novel cleavage sites beyond known Caspase-1 substrates.

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

This study shows that proinflammatory stress in beta cells increases ceramide-enriched extracellular vesicles via nSMase2, which may affect paracrine signaling in diabetes.

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.