Author

Chikashi Obuse

The University of Osaka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Koji NagaoiD· 3 shared Adele Harman· 1 shared Aiko Iwata‐OtsuboiD· 1 shared Alyssa L. RippertiD· 1 shared Beth A. Keena· 1 shared Betsy SchmalziD· 1 shared Carey‐Anne EvansiD· 1 shared Daniel C. KoboldtiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Koji NagaoORCID

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3 papers

Recent·Most cited

SmcHD1 underlies the formation of H3K9me3 blocks on the inactive X chromosome in mice

Saya Ichihara, Koji Nagao, Takehisa Sakaguchi, Chikashi Obuse, Takashi Sado

This study investigates the role of SmcHD1 in forming H3K9me3 blocks on the inactive X chromosome in mice and shows their importance in maintaining stable silencing.

Development · Jul 14, 2022Peer-reviewedGenetics

Dominant-negative mutations in CBX1 cause a neurodevelopmental disorder

Yukiko Kuroda, Aiko Iwata‐Otsubo, Kerith‐Rae Dias, Suzanna E.L. Temple, Koji Nagao, Lachlan De Hayr, Ying Zhu, Shin-Ya Isobe, Gohei Nishibuchi, Sarah K. Fiordaliso, Yuki Fujita, Alyssa L. Rippert, Samuel W Baker, Marco L. Leung, Daniel C. Koboldt, , Kosuke Izumi

This study identifies de novo CBX1 variants in three individuals with neurodevelopmental features and shows they cause dominant-negative effects by disrupting HP1β chromatin binding.

bioRxiv · Sep 29, 2020 · PreprintGenetics

Genome-wide stability of the DNA replication program in single mammalian cells

Saori Takahashi, Hisashi Miura, Takahiro Shibata, Koji Nagao, Katsuzumi Okumura, Masato Ogata, Chikashi Obuse, Shin‐ichiro Takebayashi, Ichiro Hiratani

This study introduces scRepli-seq, a single-cell DNA replication sequencing method, and shows replication domain organization is conserved in mouse embryonic stem cells, with some cell-to-cell heterogeneity linked to developmental plasticity.

Nature Genetics · Feb 25, 2019Peer-reviewedGenomics