Author

Ching Shang

Gilead Sciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Genetics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Euan Angus AshleyiD· 3 shared Kathia Zaleta-RiveraiD· 3 shared Matthew Thomas WheeleriD· 3 shared Alexandra DainisiD· 2 shared Alexandre J. S. RibeiroiD· 2 shared Beth L. PruittiD· 2 shared Pablo Cordero· 2 shared Victoria Nicole ParikhiD· 2 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Euan Angus AshleyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Allele-specific silencing ameliorates restrictive cardiomyopathy due to a human myosin regulatory light chain mutation

Kathia Zaleta-Rivera, Alexandra Dainis, Alexandre J. S. Ribeiro, Pablo Cordero, Gabriel R. Rubio, Ching Shang, Jing Liu, Thomas Finsterbach, Victoria Nicole Parikh, Shirley C. Sutton, Kinya Seo, Nikita Sinha, Nikhil Jain, Yong Huang, Roger J. Hajjar, , Euan Angus Ashley

This paper demonstrates that allele-specific RNAi therapy reduces disease-causing mutations in a mouse model of restrictive cardiomyopathy, improving cardiac function and reducing pathological markers.

Circulation · Jul 18, 2019Peer-reviewedMolecular Biology

Dissociation of disease phenotype and allele silencing in hypertrophic cardiomyopathy

Alexandra Dainis, Kathia Zaleta-Rivera, Alexandre J. S. Ribeiro, Andrew Chia Hao Chang, Ching Shang, Feng Lan, Paul W. Burridge, Joseph C. Wu, Alex Chia Yu Chang, Beth L. Pruitt, Matthew Thomas Wheeler, Euan Angus Ashley

This study compares two allele-specific silencing strategies in a human model of hypertrophic cardiomyopathy, finding that reducing both alleles improves contractility more than targeting only the disease allele.

bioRxiv · Jun 12, 2019 · PreprintGenetics

Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure

Pablo Cordero, Victoria Nicole Parikh, Ayça Erbilgin, Ching Shang, Kevin S. Smith, Frederick E. Dewey, Kathia Zaleta-Rivera, Michael P. Morley, Jeffrey Brandimarto, Nicole L. Glazer, Aleksandra Pavlović, Christine Schomisch Moravec, W.H. Wilson Tang, Jamie Viterna, Christine Malloy, , Euan Angus Ashley

The paper identifies PPP1R3A as a central cardioprotective factor in pressure overload heart failure by analyzing gene network rewiring in human hearts.

bioRxiv · Nov 4, 2017 · PreprintGenomics