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Allele-specific silencing ameliorates restrictive cardiomyopathy due to a human myosin regulatory light chain mutation

This paper demonstrates that allele-specific RNAi therapy reduces disease-causing mutations in a mouse model of restrictive cardiomyopathy, improving cardiac function and reducing pathological markers.

Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure

The paper identifies PPP1R3A as a central cardioprotective factor in pressure overload heart failure by analyzing gene network rewiring in human hearts.

Tracing co-regulatory network dynamics in noisy, single-cell transcriptome trajectories

SCIMITAR infers progression trajectories and regulatory networks from single-cell transcriptomes, identifying progression-associated genes and co-regulatory states in neural differentiation.

Rich structure landscapes in both natural and artificial RNAs revealed by mutate-and-map analysis

The paper introduces M2-REEFFIT, a method to reconstruct RNA secondary structure landscapes, showing both natural and artificial RNAs can exhibit complex, multi-state structures.

MOHCA-seq: RNA 3D models from single multiplexed proximity-mapping experiments

MOHCA-seq provides nucleotide-resolution RNA 3D structure models from single experiments, revealing new insights into ligand-induced conformational changes in riboswitches.

Correcting a SHAPE-directed RNA structure by a mutate-map-rescue approach

The paper corrects an erroneous SHAPE-directed RNA structure inference using a mutate-map-rescue approach and identifies a functional conformational state in 16S rRNA.