Author

Chris Tyler-Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 5 Genetics· 3

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:variant calling· 5 Assay:whole-genome sequencing· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Research Focus:GWAS / association mapping· 3 Research Focus:benchmarking· 2

Frequent Co-Authors

Yali XueiD· 3 shared Beiyuan FuiD· 2 shared Benjamin M SkinneriD· 2 shared Carol Churcher· 2 shared Carole A Sargent· 2 shared Dan MasoniD· 2 shared Fengtang YangiD· 2 shared John WrightiD· 2 shared

Activity by Year

2014-2016 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersGenomics

Yali XueORCID

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Author profile →

8 papers

Recent·Most cited

A direct multi-generational estimate of the human mutation rate from autozygous segments seen in thousands of parentally related individuals

Vagheesh M Narasimhan, Raheleh Rahbari, Aylwyn Scally, Arthur Wuster, Dan Mason, Yali Xue, John Wright, Richard C Trembath, Eamonn R Maher, David A van Heel, Adam Auton, Matthew E Hurles, Chris Tyler-Smith, Richard Durbin

The paper estimates the human mutation rate using autozygous segments from 3,222 British-Pakistani individuals, finding a lower mutation rate than previous estimates and population-specific mutational patterns.

bioRxiv · Jun 17, 2016 · PreprintGenomics

Health and population effects of rare gene knockouts in adult humans with related parents

Vagheesh Narasimhan, Karen Hunt, Dan Mason, Christopher L Baker, Konrad Karczewski, Michael Barnes, Anthony Barnett, Chris Bates, Srikanth Bellary, Nick Bockett, Kristina Giorda, Chris Griffiths, Harry Hemingway, Zhilong Jia, Ann Kelly, , David van Heel

The paper estimates the health effects of rare gene knockouts in adults by analyzing exome sequencing data and health records, finding no significant disease associations.

Science · Apr 22, 2016Peer-reviewedGenomics

Population-Scale Sequencing Data Enables Precise Estimates of Y-STR Mutation Rates

Thomas Willems, Melissa Gymrek, G. David Poznik, Chris Tyler-Smith, The 1000 Genomes Project Chromosome Y Group, Yaniv Erlich

This study estimates Y-STR mutation rates using population-scale sequencing data and identifies factors influencing mutation rates and their genomic impact.

bioRxiv · Apr 9, 2016 · PreprintGenomics

The pig X and Y chromosomes: structure, sequence and evolution

Benjamin M Skinner, Carole A Sargent, Carol Churcher, Toby Hunt, Javier Herrero, Jane Loveland, Matt Dunn, Sandra Louzada, Beiyuan Fu, William Chow, James Gilbert, Siobhan Austin-Guest, Kathryn Beal, Denise Carvalho-Silva, William Cheng, , Chris Tyler-Smith

This paper presents improved assemblies and gene annotations for the pig X and Y chromosomes, revealing evolutionary mechanisms and gene content differences compared to other mammals.

Genome Research · Nov 11, 2015Peer-reviewedGenomics

Iron Age and Anglo-Saxon genomes from East England reveal British migration history

Stephan Schiffels, Wolfgang Haak, Pirita Paajanen, Bastien Llamas, Elizabeth Popescu, Louise Lou, Rachel Clarke, Alice Lyons, Richard Mortimer, Duncan Sayer, Chris Tyler-Smith, Alan Cooper, Richard Durbin

The paper analyzes ancient genomes from Iron Age and Anglo-Saxon periods in East England to estimate the genetic impact of migrations on modern British populations.

bioRxiv · Jul 17, 2015Genetics

Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations

Marc Haber, Massimo Mezzavilla, Yali Xue, David Comas, Paolo Gasparini, Pierre Zalloua, Chris Tyler-Smith

This study analyzes genome-wide variation in Armenians to show their origin from Bronze Age mixing of multiple populations and their genetic affinity to Neolithic Europeans.

bioRxiv · Feb 18, 2015Genetics

Expansion of the HSFY gene family in pig lineages

Benjamin M Skinner, Kim Lachani, Carole A Sargent, Fengtang Yang, Peter JI Ellis, Toby Hunt, Beiyuan Fu, Sandra Louzada, Carol Churcher, Chris Tyler-Smith, Nabeel A Affara

This study investigates the HSFY gene family in pigs and other suids, finding two amplified variants with potential roles in spermatogenesis and fertility.

bioRxiv · Dec 19, 2014Genetics

Human genomic regions with exceptionally high or low levels of population differentiation identified from 911 whole-genome sequences

Vincenza Colonna, Qasim Ayub, Yuan Chen, Luca Pagani, Pierre Luisi, Marc Pybus, Erik Garrison, Yali Xue, Chris Tyler-Smith

The paper identifies genomic regions with high or low population differentiation using 911 whole-genome sequences, finding that highly differentiated sites are enriched for positive selection.

Genome Biology · Jun 30, 2014Peer-reviewedGenomics