Author

Yuan Chen

Imperial College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genomics· 3 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Anhao Guo· 1 shared Antonio Di MaioiD· 1 shared Charalampos RallisiD· 1 shared Chris Tyler-Smith· 1 shared Claire E. TurneriD· 1 shared Cristina CotobaliD· 1 shared Daniel C Jeffares· 1 shared Danny A Bitton· 1 shared

Activity by Year

2014-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperGenomics

Anhao Guo

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5 papers

Recent·Most cited

M1 protein expression determines niche-specific spread of Streptococcus pyogenes

Kristin K. Huse, Elita Jauneikaite, Nicola N. Lynskey, Lucy Reeves, Mark Reglinski, Matthew K. Siggins, Claire E. Turner, Virginia Tajadura‐Ortega, Yuan Chen, Antonio Di Maio, Wengang Chai, Yan Liu, Lucy Lamb, Shiranee Sriskandan

This study shows that secreted M protein, not cell-surface M protein, is critical for lymphatic survival and systemic infection of Streptococcus pyogenes in mice.

bioRxiv · Feb 11, 2026 · PreprintMicrobiology

Homology-independent targeted integration in vivo restores Cldn11 deficiency in mouse Sertoli cells and spermatogenesis

T Zhang, Anhao Guo, Hanben Wang, Yuan Chen, Lufan Li, Xin Wu

This study uses HITI gene editing in mouse Sertoli cells to restore Cldn11 function and rescue spermatogenesis and fertility in Cldn11-deficient mice.

bioRxiv · Dec 25, 2025 · PreprintGenomics

The Pulmonary Microbial Signatures of Early Stages of Severe Infection in Children

Hao Wu, Yinghu Chen, Dengming Lai, Wei Li, Mingming Zhou, Fang Shu, Yuan Chen, Ping Guo, Yu Wang, Xiaofeng Chen, Xuan Nie, Ran Tao, Lingfeng Mao, Qiang Shu, Shiqiang Shang

This study analyzes microbial communities in children with early severe pulmonary infections to identify clinical correlations and ecological interactions.

bioRxiv · Aug 25, 2025 · PreprintPathology

Skip and bin: pervasive alternative splicing triggers degradation by nuclear RNA surveillance in fission yeast

Danny A Bitton, Sophie R Atkinson, Charalampos Rallis, Graeme C Smith, David A Ellis, Daniel C Jeffares, Yuan Chen, Michal Malecki, Sandra Codlin, Michal Lubas, Jean-Francois Lemay, Francois Bachand, Cristina Cotobal, Samuel Marguerat, Juan Mata, , Jurg Bahler

This study identifies pervasive alternative splicing in fission yeast, showing that exon-skipping transcripts are mostly non-functional and degraded by nuclear RNA surveillance.

Genome Research · Apr 16, 2015Peer-reviewedGenomics

Human genomic regions with exceptionally high or low levels of population differentiation identified from 911 whole-genome sequences

Vincenza Colonna, Qasim Ayub, Yuan Chen, Luca Pagani, Pierre Luisi, Marc Pybus, Erik Garrison, Yali Xue, Chris Tyler-Smith

The paper identifies genomic regions with high or low population differentiation using 911 whole-genome sequences, finding that highly differentiated sites are enriched for positive selection.

Genome Biology · Jun 30, 2014Peer-reviewedGenomics