Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus
C. Guyon, Nada Jmari, Francine Padonou, Yen-Chin Li, Olga Ucar, Noriyuki Fujikado, Fanny Coulpier, Christophe Blanchet, David E. Root, Matthieu Giraud
The paper identifies Clp1-mediated 3’UTR shortening as a post-transcriptional mechanism enhancing transcript stability of Aire-sensitive genes in thymic medullary epithelial cells.
eLife · Apr 27, 2020Peer-reviewedGenomics