Matthieu Giraud

This study characterizes a rat model with a NFKB2 mutation, revealing systemic immunodeficiency with thymic and peripheral lymphoid defects.

This study identifies HIVEP3 as a critical regulator of thymic epithelial maturation and self-antigen expression, with its deficiency causing chronic inflammation.

This study generates functional thymic epithelial cells from iPSCs that support T cell development and dendritic cell differentiation in vitro.

The paper identifies Clp1-mediated 3’UTR shortening as a post-transcriptional mechanism enhancing transcript stability of Aire-sensitive genes in thymic medullary epithelial cells.