Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humans
Séverin Coléon, Rasangi Pathirage, Wenge Ding, Elizabeth S. Van Itallie, Katayoun Mansouri, Lorie Marchitto, Derek W. Cain, Xiaozhi Lu, Varsha Kumari, Laura L. Sutherland, Robert Parks, Andrew Foulger, Thingochuong Le, Lena M. Smith, Joena Bal, , Kevin O. Saunders
This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.
bioRxiv · May 30, 2026 · PreprintImmunology