Robert Parks

This study compares CD8+ T cell and antibody responses in non-human primates using different ratios of modified and unmodified mRNA-LNP vaccines with IL-12 boosting.

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

This study shows that a conventional H1 HA trimer vaccine elicits stem-directed antibodies in rhesus macaques that provide broad protection against H1N1 and H5N1 influenza.

This study investigates the structural and antigenic diversity of Henipavirus and Parahenipavirus glycoproteins using cryo-EM and crystal structures, revealing new epitopes and insights for vaccine development.

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

The paper isolates glycan-reactive antibodies from HIV-1 vaccine trial participants and finds they neutralize diverse HIV strains and show broad cross-reactivity against other pathogens.

This paper designs SARS-CoV-2 RBD immunogens that shift immune responses towards conserved epitopes, improving cross-reactivity against variants.

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

The paper identifies a pan-betacoronavirus antibody that binds the S2 subunit of spike proteins and induces Fc-dependent antiviral responses, offering insights into non-neutralizing antibody protection.

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.