Kevin O. Saunders

The paper investigates whether genetically diverse B-cell receptor responses in simian-HIV infected macaques converge functionally, finding that functional convergence does not require genetic convergence.

This study shows that intranasal vaccination with a synthetic spike protein and adjuvants elicits durable mucosal IgA and protects against zoonotic SARS-like coronaviruses.

The paper shows that B cell receptor signaling sets limits on the selection of functional mutations in antibodies, with mid-affinity antigens showing optimal neutralization.

The paper shows that boosting at the same site as the initial immunization preferentially engages bnAb lineage precursors in secondary germinal centers, while contralateral boosting recruits naive and non-specific memory B cells.

This study investigates the structural and antigenic diversity of Henipavirus and Parahenipavirus glycoproteins using cryo-EM and crystal structures, revealing new epitopes and insights for vaccine development.

This study shows that vaccination of macaques with an Env-ferritin nanoparticle rapidly elicits V2-apex broadly neutralizing antibodies with immunogenetic features that may be applicable to humans.

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

This study isolates and characterizes neutralizing antibodies against HCoV-229E, showing one antibody induces conformational changes in the viral spike protein.

This paper describes a user-managed 100 keV electron microscope setup for structural virology, enabling high-quality cryo-EM data collection and analysis within a laboratory setting.

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

This paper designs SARS-CoV-2 RBD immunogens that shift immune responses towards conserved epitopes, improving cross-reactivity against variants.

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.