Phagocytosis of SARS-CoV-2 Nucleocapsid- and RNA-Containing Immune Complexes Drives Inflammatory Cytokine Production and Endothelial Dysfunction
Johannes S. Gach, Daniel Kim, Khoa Vu, Michaela Ellen Marshall, Christopher Cachay, Aminah A. Rangwala, Gius Kerster, Delia F. Tifrea, Eric M. Pearlman, Matthew Zahn, Marit J. van Gils, Christopher C.W. Hughes, Donald N. Forthal
This study investigates how SARS-CoV-2 RNA and nucleocapsid-containing immune complexes drive inflammation and endothelial dysfunction through Fcγ receptor and TLR-8 pathways.
PLoS Pathogens · Oct 29, 2026Peer-reviewedImmunology